The letters S, O, U, L, S can be unscrambled into 12 words, including one anagram that uses every letter: SOLUS. The highest-scoring common word is LOSS (4 points).
SOULS is the plural of SOUL, which means:
Definitions from WordNet 3.1, Princeton University.
SOULS is valid in the ENABLE word list used by many word game apps. In everyday English it is fairly common: seen regularly in books, news and online. Points are face values only, without board bonuses.
Words that use all 5 letters exactly once.
12 words, longest first. Faded words are valid in word games but rarely used in everyday English.
Words you can make with all the letters of SOULS plus one more. Handy when there is a free tile on the board.
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